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Histone acetylation is enhanced in B cell germinal centers and derived leukemias. This is amenable to therapeutic methods, but the contribution of metabolism and its role in modifying therapy response is unclear. Semenzato, and leveraging our orthogonal experience, we are studying the role of ACLY in B cell differentiation and proliferation in health and illness. De novo sterol synthesis is elevated in pancreatic most cancers cells. Moreover, its ldl cholesterol homeostasis is deregulated in tumor-initiating pancreatitis. We found that cholesterol supplementation promotes metaplasia of pancreatic acinar cells.

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